FRAXA Grant to John Larson, PhD — University of Illinois Chicago

John Larson, PhD

FRAXA Awards:

$40,000 in 2000

Synaptic Plasticity and Olfactory Learning in Fragile X:

Regulation of Group I Metabotropic Glutamate Receptor Trafficking in a Fragile X Animal Model

by Michael Tranfaglia, FRAXA, 4/1/2007

Abnormalities of metabotropic glutamate pathways in the fragile X brain have been demonstrated in many ways by many research groups, and these appear to be the cause of many or most of the symptoms of fragile X. However, this research group is the only one to date to study the important question of how mGluRs move around in fragile X neurons, compared to normal. As in so many biological processes, metabotropic glutamate receptor function is not fixed and static; rather, these receptors move around in the cell membrane, from one part of the synapse to another, and they move in and out of the cell surface membrane. All of these movements are controlled and tightly regulated, and there is reason to suspect that the absence of FMRP affects these processes.

Understanding the mechanisms underlying these movements will help us to understand the central abnormalities in fragile X, and it may lead to new targets for drug discovery. Perhaps even more importantly, understanding these mechanisms will help us improve fragile X treatments using mGluR antagonists.

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Synaptic Plasticity and Olfactory Learning in a Mouse Model of Fragile X Syndrome

by Katie Clapp, FRAXA, 7/1/2000

This team will use olfaction (sense of smell) in mice as a neuro-behavioral model system for human memory. They will characterize olfactory sensitivity, learning, and memory in FMR1 knockout mice as compared to wild-type (normal control) mice.