Vitaly Klyachko, PhD — Washington University

Translation-independent functions of FMRP in excitability, synaptic transmission and plasticity

klyachko-wash univ. 2012with

Ziv Rotman, PhD, Postdoctoral Fellow
Pan-Yue Deng, PhD, Postdoctoral Fellow

FRAXA Awards:

$70,000 in 2013
$70,000 in 2012

 

While long-term plasticity (LTP) is thought to play an important role in learning and memory and has been studied extensively in FX, short-term plasticity (STP) is widely believed to control information processing, working memory, and decision making. Dr. Klyachko will explore STP in FX, namely looking at presynaptic calcium dynamics as a major underlying cause of the STP defects. Because their early data indicate that the mechanism has a cell-autonomous presynaptic origin and do not depend on the activation of Gp1 mGluRs or protein translation, this suggests a major novel locus of FX pathology. Dr. Klyachko will test if specific molecular targets can rescue STP and information processing defects in the neurons of FX knock-out mice.

Along with this work, the team discovered another clue to the Fragile X Syndrome mystery along with researchers led by Dr. Stephen Warren at Emory University: Rare case uncovers missing clue to Fragile X