A Medication Guide for Fragile X Syndrome

Introduction Recent dramatic advances in the field of psychopharmacology have made possible treatments which were inconceivable ten years ago. Many conditions previously viewed as intractable are now almost trivially simple to treat. Along with these advances in treatment have come much better understanding of the basic neuronal processes involved in psychiatric disorders, and the prospect of far more advanced therapies to come. Fragile X syndrome is by far the leading cause of inherited mental retardation around the world; it is, arguably, the most common serious genetic disease in humans; it is also a complex and highly variable neuropsychiatric disorder. Many individuals with Fragile X, especially females, exhibit less overt developmental delay, but still suffer from subtler dysfunction of attention or socialization which may be every bit as treatable as more severe behavioral disturbances. Much of the attention given to the psychopharmacology of Fragile X is devoted to treatment of more