Our lastest Fragile X Research Grants 2017 Recipient is the team of Probal Banerjee, PhD, Alexandra Marsillo, and Tatyana Budylin from College of Staten Island with thier reseach project: Correcting Fragile X-associated Deficits by Targeting Neonatal PKCepsilon Signaling in the Brain.
Although the clinical trials failed to show efficacy in the patient population and Novartis and Roche discontinued their fragile X development programs, Dr. Senter has worked with Mark Bear, PhD to carefully review parent observations. Those caregiver reports suggested tolerance to mGlu5 antagonists antagonists developed quickly, consistent with some preclinical findings in the mouse model.
Yes, we all know the signs of fragile X anxiety: Ears begin turning red followed by incessant pacing, heavy breathing, stiffening body, flapping, jumping, avoidance or yelling. Sometimes, it’s the more severe screaming, pinching, scratching, biting and general tearing things up or, worse, the nuclear meltdown.