$28,000 in 2001
$37,000 in 2000
Molecular Interactions Between FMRP, the Fragile X Protein, and Protein Translation Apparatus
The primary role of the fragile X protein (FMRP) in normal cells appears to be the regulation of protein synthesis in response to activity in a number of signaling pathways. This research groups focuses on understanding the specific molecular interactions which regulate protein synthesis, and how they are altered in fragile X. Dr. Bagni has moved from the University of Rome to VIB in Leuven, Belgium.
by Michael Tranfaglia, MD, 4/1/2011
Research has shown that the fragile X protein, FMRP, has several possible functions within neurons. It appears to shuttle between the nucleus and the cytoplasm of cells, and it is present in dendrites and at synapses. Moreover, FMR1 mRNA is translated at synapses in response to synaptic activity. Dr. Bagni’s FRAXA grant enabled her to further define these processes: how the FMR1 mRNA gets to the dendrites, how the protein FMRP is made there and how it then influence synthesis of other proteins at the synapses. It also enabled her to identify and characterize some messenger RNAs that interact with FMRP at synapses.