|Dr. Rattazzi's studies on Prospects for gene therapy in the fragile X
by Katie Clapp, 4/1/2011
Dr. Rattazzi's research was aimed at exploring ways to transfer the FMR1 gene across the blood-brain-barrier
in normal rats and mice, and then in FMR1 knockout mice.
The techniques he studied with FRAXA funding were 1)to use a fragment of the HIV Tat protein to target the
DNA-carrying vectors to the neucleus of neurons and 2) to use the adeno-associated virus as a vehicle to carry vectors.
Dr. Rattazzi published a paper with results, at
Sadly, Dr. Mario Rattazzi passed away in the summer of 2004 after a battle with cancer.