|APP and Abeta in Fragile X
James Malter, PhD, Principal Investigator
Cara Westmark, PhD, Assistant Investigator
Cara Westmark, PhD, Co-Investigator (2008-9)
$60,000 in 2009
$60,000 in 2008
$10,000 in 2008
The fragile X protein, FMRP, is known to regulate APP, a protein important to the pathology of Alzheimer’s Disease. APP may also contribute to the pathology of fragile X, and its major metabolite, Aß, may contribute to abnormal protein synthesis via a positive feedback loop. This project seeks to restore normal dendritic protein synthesis in fragile X mice by breaking into this loop.