|Synaptic Function of FMRP
Dr. Bagni published an article entitled Signals, synapses, and synthesis: how new proteins control plasticity on this topic in 2009: visit
by Michael Tranfaglia, MD, 8/2000, 4/1/2011
Research has shown that the fragile X protein, FMRP, has several possible functions within neurons. It appears to shuttle between the nucleus and the cytoplasm of cells, and it is present in dendrites and at synapses. Moreover, FMR1 mRNA is translated at synapses in response to synaptic activity. Dr. Bagni's FRAXA grant enabled her to further define these processes: how the FMR1 mRNA gets to the dendrites, how the protein FMRP is made there and how it then influence synthesis of other proteins at the synapses. It also enabled her to identify and characterize some messenger RNAs that interact with FMRP at synapses.