22
DEC
2014

Family’s Search For Fragile X Drug Finds Frustration, Hope

on NPR Morning Edition by Jon Hamilton Read or listen here: http://www.npr.org/blogs/health/2014/12/22/371502800/a-familys-long-search-for-fragile-x-drug-finds-frustration-hope
15
AUG
2014
Mike Tranfaglia, MD, FRAXA Chief Scientific Officer

Fragile X Clinical Trials: is the mGluR Theory still valid?

POSTED BY MICHAEL TRANFAGLIA MD Why have clinical trials failed?  Tolerance and Dose Range In my opinion, the Fragile X clinical trials of AFQ056 sponsored by Novartis failed because of a dose range that was inadequate for fragile X, and because of the unexpected development of...
08
NOV
2013
Elizabeth Higgins Clark

This Is My Brother, speech by Elizabeth Clark at FRAXA’s Fall X Ball

In a heartfelt, humorous and insightful speech, Elizabeth Higgins Clark imparts the inspiration and love she has received from her brother, David, who has Fragile X Syndrome.  Fragile X is the most common form of genetically transferred intellectual disability. Clark gave the...
02
JUN
2013

Olivier Manzoni, PhD — INSERM, Marseille, France

with Daniela Neuhofer, PhD, Postdoctoral Fellow (2012-) Marja Sepers, PhD, Postdoctoral Fellow (2009) FRAXA Awards: $45,000 in 2012, renewed for $45,000 in 2013 $45,000 in 2009   Endocannabinoid mediated synaptic plasticity in fragile X mice Drs. Neuhofer (First from the...
21
MAY
2013

Learn More about Fragile X – Links

Fragile X site – Centers for Disease Control (CDC) — Comprehensive site with multimedia for all audiences. Also en espagnol Dr. Mike’s psychiatry blog — Research & treatment notes by FRAXA co-founder, medical director, and FX parent, Dr. Mike...
11
JAN
2013

Clinical Trials FAQ ← frequently asked questions

Question: How do families decide which trial is best for them? Answer: Each of the trials has different requirements for joining, so many – if not most – people will only be eligible for one trial after screening. The best way to approach this is to call the clinic contact...
13
OCT
2011

Update on new treatments for fragile X – Part 4: MMP-9 inhibitors

10/13/2011 Dr. Mike’s Psychiatry Blog When Iryna and Doug Ethell of UC Riverside showed that a known inhibitor of MMP-9 could reverse abnormalities in Fragile X knockout mice, they raised the possibility of minocycline as an off-the-shelf treatment for fragile X.